Festival organizers said Monday that Anderson's movie will open the event's 68th edition on Feb. 15. It features the voices of Edward Norton, Bill Murray, Scarlett Johansson and Tilda Swinton among others.
"Isle of Dogs" is set for release in U.S. movie theaters in March and internationally in April. It will be the first animated film to open the Berlin festival, and the fourth movie Anderson has presented in the event's competition. Most recently, he brought "The Grand Budapest Hotel" to Berlin in 2014.
German director Tom Tykwer will head the jury at the festival, which runs until Feb. 25. Other movies and jurors haven't yet been announced.
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